Demystifying extrachromosomal DNA circles: Categories, biogenesis, and cancer therapeutics

Demystifying extrachromosomal DNA circles: Categories, biogenesis, and cancer therapeutics

Blog Article

Since the cardboard sweet stand advent of sequencing technologies in the 1990s, researchers have focused on the association between aberrations in chromosomal DNA and disease.However, not all forms of the DNA are linear and chromosomal.Extrachromosomal circular DNAs (eccDNAs) are double-stranded, closed-circled DNA constructs free from the chromosome that reside in the nuclei.

Although widely overlooked, the eccDNAs have recently gained attention astros big chain necklace for their potential roles in physiological response, intratumoral heterogeneity and cancer therapeutics.In this review, we summarize the history, classifications, biogenesis, and highlight recent progresses on the emerging topic of eccDNAs and comment on their potential application as biomarkers in clinical settings.